UAM-X

Aromatherapy in the Management of

Psychiatric Disorders

Clinical and Neuropharmacological Perspectives

NICOLETTE PERRY AND ELAINE PERRY

Abstract

Aromatherapy is currently used worldwide in the management of chronic pain, depression, anxiety, some cognitive disorders, insomnia and stress-related disorders. Although essential oils have been used, reputedly effectively, for centuries as a traditional medicine, there is very little verified science behind this use. The pharmacology of the essential oils and/or their single chemical constituents, therefore, remains largely undiscovered. However, accumulating evidence that inhaled or dermally applied essential oils enter the blood stream and, in relevant molecular, cellular or animal models, exert measurable psychological effects, indicates that the effects are primarily pharmacological. This review includes evidence from the limited number of clinical trials that have been published of ‘psychoaromatherapy’ in relation to psychiatric disorders, together with evidence from mechanistic, neuropharmacological studies of the effects of essential oils in relevant in vitro and in vivo models. It is concluded that aromatherapy provides a potentially effective treatment for a range of psychiatric disorders. In addition, taking into account the available information on safety, aromatherapy appears to be without the adverse effects of many conventional psychotropic drugs. Investment in further clinical and scientific research is clearly warranted.

Aromatherapy-in-Psychiatric-Disorders.pdf

Chemical composition and antifungal activity of essential oils

of seven Moroccan Labiatae against Botrytis cinerea Pers: Fr.

CHEBLI BOUCHRA, MOHAMED ACHOURI, L.M. IDRISSI HASSANI, MOHAMED HMAMOUCHI.

Abstract

Essential oils of seven Moroccan Labiatae were chemically analysed by GC-MS and evaluated for their in vitro antifungal activity against Botrytis cinerea. Among them, Origanum compactum and Thymus glandulosus greatly inhibited the growth of the mycelium. The inhibition of Botrytis cinerea was 100% for both oils at 100 ppm, while the IC50s were 35.1 and 79.2 ppm, respectively. Mentha pulegium exhibited moderate activity at 250 ppm since the inhibition of the mycelial growth was 58.5% and the IC50 was 233.5 ppm. The main constituents of the studied oils were also examined. Thymol and carvacrol that are the two main constituents of Thymus glandulosus and Origanum compactum exhibited the strongest antifungal activity with 100% of inhibition at 100 ppm, respectively.

Keywords: Moroccan Labiatae; GC-MS; antifungal activity; Botrytis cinerea